Cobalamin Malabsorption


Cobalamin malabsorption refers to a genetic abnormality by which the vitamin B12, also known as cobalamin, fails to be absorbed from the intestine. This condition occurs secondary to the absence of a specific binding receptor in the lower intestine (the ileum) for intrinsic factor-cobalamin complex (IF-cbl). This is a rare disease that tends to affect Giant Schnauzers, Border Collies, and Beagles. In the Giant Schnauzer, it is inherited as a simple autosomal recessive trait. Symptoms generally appear at 6 to 12 weeks of age in Giant Schnauzers, and around four to six months in Border Collies.